Literature Search

Today we will be using online resources to look up chemical and physical properties of compounds. Let’s start off by visiting the library’s
resource site for CH 224. It is a good idea to use the library resource page links, since it will grant you access to the databases required. This site provides several valuable online resources for finding information on chemicals you use in laboratory. The best place to start looking is
the Sigma-Aldrich online catalog. Sigma-Aldrich is a major chemical supplier.
Their website often contains chemical and physical properties and spectral
information of the chemicals they sell. For the purposes of this video, we’ll do
a simple example together: acetone. Type “ acetone” into the search
bar in the top right and search. Click on the first search result. On the right-hand side, you see the structure of acetone. On the left-hand side, underneath “acetone,”
are several pieces of useful information: CAS Number, chemical formula, molecular weight,
and the materials safety data sheet (MSDS). The MSDS shows any information related to
the safe handling of the chemical involved. You can also find the price of
your compound on this page. Next let’s go back to the library resource page
to find out more about our compound. You can also use a website called ChemSpider
to find the physical properties of most compounds. Click on the entry for 2-propanone,
a synonym for acetone. This gives you many of the other chemical
and physical properties you may not find on the MSDS or via Google search. Let’s return once again to the library
resources to find more information on the hazards associated with acetone. Scroll down to the section titled “Hazardous Properties”. If Sigma-Aldrich does not have an MSDS, then
the university’s database likely does. Click on the link “NC State MSDS Management System.” Search for the compound of interest (acetone)
and click on the entry to view the MSDS. Return to the library resource page for CH 224. Often times we also need spectral information
like IR or NMR of the compounds we’re using. Click on the link for “AIST’s SDBS”
and follow the directions to the search page. Search for spectra by name or CAS number. Select the types of spectral information you
need, 1H-NMR and IR for Exp. 1 in CH 224. Click on the results corresponding to your compound. Links to spectral information are on the left side menu. You will need to print a copy of the spectra for your compound so you can turn them in with your report. Let’s return to the library resource page for CH 224
to find a synthesis of your compound. Scroll to the “Preparation or Synthesis” section. You can use either Reaxys or Scifinder. For Scifinder you will need to register with them, which you can do for free through the library’s subscription. First let’s use Reaxys. Click the link “Finding a Method of Synthesis“. Then, click “Reaxys through NC State’s library”. Click “Reactions.” You can search for a particular
compound in several ways. The simplest is to click “Create Structure Template
from Name” below the structure editor box, enter the name of the compound of interest,
click submit, and you have it drawn for you. Make sure “Product” is selected as the
role of the compound in the reaction. Then click “search reactions.” Several reactions with conditions will
show up with links to the literature from which it came if you want more information. Let’s return to the library resource page to go through using SciFinder to find syntheses of your compound. Go to the “Finding a Method of Synthesis“ page, scroll down to “Other possible sources”
and click “SciFinder.” Under “Access to SciFinder,
click “Scifinder is available through NCSU libraries.” From here, if you haven’t done so already,
register with SciFinder. Once you have registered, return to this page and click the banner containing SciFinder’s
logo to access the database. Once you’ve signed in, on the left menu
click “chemical structure” under substances. Click on the structure editor box and use
the tools to draw your compound. On the right side of the structure editor,
under “get substances that match your query,” click the circle next to “exact search.” Click “OK” to exit the editor, and click search. Click the entry for your compound. Click “Get Reactions,” make sure “product”
is selected and click “OK”. Much like Reaxys, this shows the different reactions
with their conditions, yields, and original papers.

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