Bonnie Bassler (Princeton) Part 2: Vibrio Cholerae Quorum Sensing and Novel Antibiotics

8 Replies to “Bonnie Bassler (Princeton) Part 2: Vibrio Cholerae Quorum Sensing and Novel Antibiotics

  1. Fascinating, really exciting, and presented in a way that is comprehensible even to a non-scientist like myself. Thanks for such wonderful work on both fronts, the research, and communicating it to the rest of us!

  2. Great video. You should do this for LYME DISEASE, as now the CDC is reporting that well over 300,000 people/yr are becoming infected & this now passes well beyond the number of cases of AIDS/HIV+. This has become a global problem & real estimates are anywhere from 1-3 Million of new cases per year. The agent for Lyme Disease, Borrelia burgdorferi, produces outer surface proteins (OSP-C & OSP-A) which are most likely then involved in quorum sensing. The OSP-A is produced more in ticks & the OSP-B is produced more in humans, which sounds like it is the basis for something that can be exploited.

    There have been a few studies over the years that now implicates Borrelia spirochetes in a number of diseases including but not limited to Mulitiple Sclerosis, Alzheimer's Disease, Fibromyalgia, & Morgellon's Disease. So your work can have an impact on millions & millions of people, especially those who have been misdiagnosed due to such poor antibody testing.

  3. Quetion if cholera turns virulence genes on at low cell density then when it swallowed it should be in contact with ur intestinal flora and then be inhibeted by AI2 secreted by intestinal flora

  4. In theory, the side-effects of the autoinducers should not matter, since they are given during the high-virulence phase and they would be produced in the low-virulence phase by the bacterium anyway. That will make for an interesting FDA process.

  5. Very promising, great team work and lecture. Ideally while choosing the proper bacterial "language", good bacteria can remain active and bad bacteria are disabled.

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